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Hypertension, vascular inflammation and renal inflammation are characteristic of systemic lupus erythematosus (SLE), a multisystem autoimmune illness that’s complex and poorly understood. Oxidation products of arachidonic and other fatty acids, termed isolevuglandins (isoLG) result in formation of post-translational protein modifications which might be immunogenic. We demonstrate isoLG enrichment in dendritic cells (DCs), B cells, and plasma cells from juvenile female B6.SLE123 mice. In adult B6.SLE123 and NZBWF1 mice, isoLG adducts are enriched in plasma cells and splenic DCs in comparison with C57Bl/6 and NZW mice respectively. Treatment with the isoLG-scavenger 2 bromoethanol-hydroxybenzylamine (2-HOBA) lowered blood strain, improved renal function, and attenuated renal injury. Furthermore, 2-HOBA diminished bone marrow plasma cells, complete IgG levels, and anti-dsDNA antibody titers. We additionally demonstrate that mice with SLE generate specific IgG antibodies against isoLG adducted protein, confirming the immunogenicity of isoLG adducts. Finally, we discovered that isoLG adducted peptides are markedly enriched in monocytes from patients with SLE which was accompanied by a rise in superoxide production. These findings help a role of isoLG adducts in the genesis and maintenance of systemic autoimmunity and its associated hypertension in SLE. Scavenging of isoLGs promises to be a novel therapy for this illness.

Dr. Mark Hyman:

These are information to use in the form of issues that you realize, Jeff, round meals. You’re such a master of meals as medicine. That’s the place I realized the term “Food is data.” Individuals assume I invented, I didn’t. I stole it from Jeff Bland. However the truth is, are there are their information to use within the survey of the compounds that you just talked about that we needs to be desirous about eating more of?

Section 8 – Exposure CONTROLS, Personal Protection

Engineering Controls:

Services storing or using this materials should be equipped with an eyewash facility and a security shower. Use ample ventilation to keep airborne concentrations low.

Exposure Limits CAS# 932-30-9: Personal Protective Equipment Eyes: Not accessible.

Skin:

Put on acceptable protecting gloves to prevent pores and skin publicity.

Clothes:

Wear appropriate protective clothes to forestall skin publicity.

Respirators:

Follow the OSHA respirator rules found in 29 CFR 1910.134 or European Normal EN 149. Use a NIOSH/MSHA or European Commonplace EN 149 authorized respirator if publicity limits are exceeded or if irritation or different symptoms are skilled.