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Single oral doses of phosphodiesterase inhibitors have demonstrated transient dose-associated impairment of colour discrimination (blue/green) utilizing the Farnsworth-Munsell 100-hue take a look at and reductions in electroretinogram (ERG) b-wave amplitudes, with peak results near the time of peak plasma levels. These findings are according to the inhibition of PDE6 in rods and cones, which is concerned in phototransduction within the retina. The findings were most evident one hour after administration, diminishing however still current 6 hours after administration. In a single dose study in 25 normal males, LEVITRA 40 mg, twice the utmost day by day recommended dose, didn’t alter visible acuity, intraocular pressure, fundoscopic and Prep generico slit lamp findings.