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What is Clonazolam?

Clonazolam (also known as Clonitrazolam)is a new depressant from the benzodiazepine class, which used as an anxiolytic, calming, hypnotic, relaxing muscle, an anticonvulsant, and an amnesic effect. This compound is a new research chemical derivative drug from clonazepam (Buy Klonopin Online 1mg, Rivotril) and alprazolam (Xanax).

It is reported that clonazolam is about 2.5 times more effective than alprazolam. Synthesis of clonazolam was first recorded in 1971. It has been described as the most active compound in a series of tests. It is known that clonazolam has a high activity, and concerns have been raised that it and the fluoromazoles can cause relatively higher risks than other designer benzodiazepines because of their ability to produce severe sedation and amnesia with oral administration at doses up to 0, 5 mg or 500 μg (μg). It is reported that the beginning of its action is of medium length (20-60 minutes).

Very little is known about this substance, but recently it has become easily accessible through online RC suppliers, where it is sold as a designer drug. Because of its extremely high potency, it can often be found on a brand or in solutions. The ingestion of clonazolam powder is unsafe because of its activity in the microgram range and the ease with which it can lead to many days of tripping out of reality.

It should be noted that the sudden discontinuation of benzodiazepines may be potentially hazardous to health or life, with regular admission for extended periods of time. Such a sharp cessation sometimes leads to seizures or death. It is strongly recommended to reduce its dose, gradually reducing the amount taken every day for a long period, rather than abruptly stopping or giving up.

Due to the high dependence potential, as well as its alcohol-like ability to cause dangerously disinhibited conditions, it is strongly recommended that proper attention is given to the correct intake of this substance. In combination with other depressants, such as opiates, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances, death may occur. It is strongly advised not to combine these substances, especially in heavy doses.

Pharmacology:

Benzodiazepines produce various effects by increasing the efficacy and effects of neurotransmitter gamma-aminobutyric acid (GABA) acting on the receptors as a brake system. Benzodiazepines, allosteric interaction with GABA A receptors, increase the affinity of gamma-aminobutyric acid (GABA) to these receptors, thereby increasing the flow of chloride ions into neurons and increasing the inhibitory postsynaptic potential, which reduces the excitability of neurons.

The anticonvulsant properties of benzodiazepines can be partially or completely caused by binding in sodium channels.

Effects of Clonazolam?

The effects listed below are based on the subjective effects index and the personal experience of community members. The listed effects will very rarely (if ever) occur all at once, but heavier doses will increase the possibility of obtaining a full spectrum of effects. Also, negative effects become more possible at high dosages and can lead to disability or death.

Physical effects:

Sedation: This drug is extremely soothing and often leads to an overwhelming lethargic state. At higher doses, this makes users suddenly feel as if they are sleep deprived and did not sleep for days on end. This feeling of sleep deprivation increases in proportion to the dose and eventually becomes strong enough to cause a person to lose consciousness completely.

Muscle relaxation

Loss of control over the body

Dizziness

Increased libido

Inhibition of respiration

Drowsiness

Cognitive effects:

Amnesia

Disinhibition

Misconception

Suppression of analytical ability

Slowing down the thought process

Drowsiness

Paradoxical effects:

Occasionally, paradoxical reactions occur on benzodiazepines, such as increased seizures (with epileptic seizures), aggressiveness, increased anxiety, violent behavior, impulsiveness, irritability and suicidal behavior (although they are rarely found below 1%). These paradoxical effects occur with a greater frequency in people abusing recreational use, people with mental disorders, children, and patients in high-dose regimens.

Toxicity and harm:

Clonazolam has low toxicity with respect to dose. However, it is potentially fatal if mixed with depressants, such as alcohol or opioids. It is strongly recommended that harm reduction methods be used when using this substance.

Tolerance and dependence:

Clonazolam causes extremely strong physical and psychological dependence.

For sedative effects, tolerance will develop over several days of continuous use. After cessation, it returns to the baseline level after 7-14 days. However, in some cases, this can take considerably longer, in proportion to the duration and intensity of long-term use.

Clonazolam represents cross-tolerance with all benzodiazepines, which means that after its consumption, all benzodiazepines will have a reduced effect.

Termination

It is known that stopping the use of benzodiazepines is not an easy procedure; it is potentially life-threatening if you stop taking without lowering the dose for several weeks. There is an increased risk of increased blood pressure, seizures, and death. Substances that reduce the seizure threshold, such as tramadol, should be avoided during the withdrawal of this drug. Abrupt termination also causes anxiety, insomnia, and anxiety. If you want to quit after a period of regular use of clonazolam, it is safer to reduce the dose daily, for a couple of weeks, until it is close to moderate or minimal. Longer-acting diazepam or clonazepam can be substituted for benzodiazepine with a short half-life, such as alprazolam or etizolam, etc. Symptoms can still be present,

A small amount of alcohol can also help alleviate the symptoms, but it can not be used as an effective assistant in reducing the dose.

The duration and severity of withdrawal symptoms depend on some factors, including the half-life of the substance used, tolerance and duration of abuse. The main symptoms usually begin only a few days after discontinuation and persist for about a week for short-acting benzodiazepines. Benzodiazepines with a longer half-life will show withdrawal symptoms not immediately but will last longer in duration.

Overdose

An overdose of benzodiazepines may occur when the benzodiazepine is taken in extremely heavy amounts or concomitantly with other depressants. This is especially dangerous for other GABA depressants, such as barbiturates and alcohol, because they work similarly, but are linked by different mechanisms at the GABA receptors, cross-potentiating each other. For example, benzodiazepines increase the frequency with which chlorine ions bind to the GABA receptor, while barbiturates increase the duration during which these receptors are open. This can lead to dangerous conditions of oppression along with potentially lethal respiratory depression. With an overdose of benzodiazepines, emergency medical care is almost always required. This condition can easily lead to a coma,

Symptoms of an overdose of benzodiazepines may include a serious slowdown in the thought process, slurred speech, confusion, confusion, respiratory depression, coma, or death. Overdoses of benzodiazepines can be treated in a hospital environment with favorable results.

Dangerous Combinations

Although many substances are safe in themselves, they can become hazardous to health and even life-threatening in combination with others. The list below contains some common potentially dangerous combinations, but they can not cover them all. Some combinations can be relatively harmless at low doses of each substance, but can still increase the risk of unpredictable consequences.

Depressants: (1,4-Butanediol, 2M2B, alcohol, benzodiazepines, barbiturates, GHB / GBL, methaqualone, opioids). This combination potentiates muscle relaxation, amnesia, sedation and respiratory depression caused by each other. In higher doses, this can lead to a sudden, unexpected loss of consciousness along with a dangerous degree of respiratory depression. There is also an increased risk of nausea/vomiting in the unconscious state and death from induced strangulation. If nausea or vomiting occurs before loss of consciousness, the user should try to fall asleep in a restorative position or ask a friend to move into it.

Stimulants: It can be dangerous to combine depressants with stimulants because of the risk of excessive intoxication. Stimulants mask the sedative effect of depressants, which is the main factor in which most people go over their dosage and get excessive intoxication. Once the effects of the stimulant pass, the effects of the depressant will be greatly enhanced, which will lead to increased disinhibition, loss of body control and dangerous conditions of oppression. This combination can also potentially lead to severe dehydration if fluid intake is not carefully monitored. If you want to combine these substances, you must strictly confine yourself to a predetermined dosing schedule.

Dissociatives: This combination can unpredictably increase the amnesia, sedation, loss of motor control and delusions that may be caused by these substances. This can also lead to a sudden loss of consciousness, accompanied by a dangerous degree of respiratory depression. If nausea or vomiting occurs before loss of consciousness, the user should try to fall asleep in a restorative position or ask a friend to move into it.

The author has a vast knowledge of research chemicals like Clonazolam, Etizolam, Diclazepam, Flubromazolam etc With this article he has tried to explain some of the important aspects related Clonazolam, a popular research in the USA.