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Jenks BH, Iwashita S, Nakagawa Y, et al. A pilot study on the consequences of S-equol in comparison with soy isoflavones on menopausal sizzling flash frequency. J Womens Well being. 2012;21(6):674-682. 2. Aso T, Uchiyama S, Matsumura Y, et al. A pure S-equol complement alleviates sizzling flushes and different menopausal symptoms in equol nonproducing postmenopausal Japanese girls. J Womens Health. 2012;21(1):92-100. 3. Information on File. 1811 Research Report; Pharmavite LLC. 4. Tousen Y, Ezaki J, Fujii Y, Ueno T, Nishimuta M, Ishimi Y. Pure S-equol decreases bone resorption in postmenopausal, non-equol-producing Japanese girls: a pilot randomized, placebo-managed trial. Menopause. 2011;18(5):563-574. 5. Muthyala RS, エクオール（及びエクオール　サプリ） Ju YH, Sheng S, et al. Equol, a pure estrogenic metabolite from soy isoflavones: handy preparation and decision of R- and S-equols and their differing binding and biological exercise by way of estrogen receptors alpha and beta. Bioorg Med Chem.

On this examine, only ~22.8% of the inhabitants was equol producers, which is decrease than that beforehand reported [6, 15]. The gut microbiota is established immediately after start [38]. Consequently, it is formed in accordance with individual dietary and way of life habits. Our previous examine confirmed that equol manufacturing was related to the type of weight-reduction plan in addition to with life-style habits [39]. Due to this fact, individual differences within the composition of gut microbiota might be responsible for different outcomes reported in numerous studies. In recent years, microorganisms that can produce equol have been identified more. Utilizing genetic engineering methods, these microorganisms could be used for the formulation of useful foods.

Not a lot is understood about how menopause results in changes in mood, but consultants consider it’s linked to hormonal adjustments and bodily signs of menopause. However, in response to Harvard Medical School, girls with a historical past of “temper points” are more likely to expertise depression or anxiety throughout menopause.