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The results of intraoperative air or nitrous oxide on postoperative oxygen saturation (SaO2) in blood have been compared in forty patients of ASA classes 1 and a couple of undergoing elective open cholecystectomy. The incidence of hypoxemia was significantly increased in these treated with nitrous oxide than in those given air 48 hours postoperatively [18]. Hypoxemia could even have some mechanical origins. Nitrous oxide diffuses into the endotracheal tube cuff, overexpanding it, and may thus provoke upper airway obstruction, hypoxemia, and trauma in intubated patients during basic anesthesia [19].

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