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Vital to this course of is an enzyme often called an RNA-dependent RNA polymerase, or RdRp. It has one job, and it’s horrible at it. “That is an enzyme that makes a huge amount of errors when replicating,” says Roger Frutos, a molecular microbiologist on the French Agricultural Research Centre for International Growth, or timberline CIRAD. The RdRp introduces errors throughout replication, producing new viruses with slightly completely different templates. Modifications within the template are often called mutations.

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